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SNW1 and SART1
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
SNW1
SART1
Description
SNW domain containing 1
spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Nuclear Matrix
Nuclear Body
Nuclear Speck
U2-type Catalytic Step 2 Spliceosome
Catalytic Step 2 Spliceosome
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cajal Body
Nuclear Speck
U4/U6 X U5 Tri-snRNP Complex
U2-type Precatalytic Spliceosome
Catalytic Step 2 Spliceosome
Molecular Function
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Notch Binding
Protein Binding
Enzyme Binding
Nuclear Hormone Receptor Binding
Vitamin D Receptor Binding
Retinoic Acid Receptor Binding
SMAD Binding
Androgen Receptor Binding
RNA Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Viral Process
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of MRNA Splicing, Via Spliceosome
Retinoic Acid Receptor Signaling Pathway
Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Neurogenesis
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Vitamin D Receptor Signaling Pathway
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Retinoic Acid
Spliceosomal SnRNP Assembly
MRNA Splicing, Via Spliceosome
Maturation Of 5S RRNA
MRNA Cis Splicing, Via Spliceosome
Positive Regulation Of Cytotoxic T Cell Differentiation
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
mRNA Splicing - Major Pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Response to platinum-based chemotherapy in non-small-cell lung cancer (
22872573
)
Acne (severe) (
24927181
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Interacting Genes
97 interacting genes:
ABLIM3
ACTN2
ASCC2
BICD2
BYSL
C1orf216
CCDC125
CEP55
CEP70
CIR1
CWF19L2
DAXX
EP300
ERCC3
EXOSC5
FAM90A1
GABPB1
GAS2L2
GOLGA2
GRIPAP1
HDAC2
HMBOX1
HOOK2
HSF2BP
IKBKG
IKZF1
JDP2
KANK2
KRT40
LRP2BP
LZTS2
MAGEA1
MAGOHB
MAPK6
MCMBP
MEN1
MFAP1
MISP
MSL1
MTUS2
NCK2
NCOA1
NCOR1
NCOR2
NOTCH1
NOTCH3
NR0B1
NR0B2
NXF1
OCLN
ODF2
OSTF1
PABPN1
PCBD2
PGR
PICK1
PPIL1
PRKAA2
PRKAR1B
RABEP1
RARA
RB1
RBL1
RBL2
RBPJ
RINT1
RXRA
SAAL1
SART1
SIN3A
SIRT1
SKI
SMAD2
SMAD3
SMAD4
SNRNP200
SNU13
SPECC1L
STEEP1
SUMO2
TCP11L1
TEX11
TFIP11
TNNT1
TOP1
TRAF1
TRIM15
TRIM23
TRIM55
TRIM63
TTC14
USF1
VAV2
VDR
VPS39
WBP4
ZSCAN1
13 interacting genes:
APP
CHERP
HSF2BP
IGHE
MFAP1
SNW1
SRPK2
SRSF4
SUMO2
UBE2I
UBL5
WBP4
ZCCHC10
Entrez ID
22938
9092
HPRD ID
04340
10440
Ensembl ID
ENSG00000100603
ENSG00000175467
Uniprot IDs
G3V3A4
Q13573
O43290
PDB IDs
5MQF
5XJC
5YZG
5Z58
6FF4
6FF7
6ICZ
6ID0
6ID1
6QDV
6ZYM
7A5P
4PYU
5O9Z
6AHD
6QW6
6QX9
Enriched GO Terms of Interacting Partners
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