SYT11 and PLEKHO1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		SYT11	PLEKHO1
Description		synaptotagmin 11	pleckstrin homology domain containing O1
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Lysosome Lysosomal Membrane Trans-Golgi Network Plasma Membrane Synaptic Vesicle Postsynaptic Density Axon Dendrite Clathrin-coated Vesicle Membrane Vesicle Early Phagosome Neuron Projection Terminal Bouton Dendritic Spine Perikaryon Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Inhibitory Synapse Exocytic Vesicle Schaffer Collateral - CA1 Synapse Presynapse Integral Component Of Presynaptic Active Zone Membrane	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Clathrin Binding Translation Initiation Factor Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Plasma Membrane Repair Negative Regulation Of Cytokine Production Vesicle Fusion Autophagy Learning Memory Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Dopamine Secretion Negative Regulation Of Endocytosis Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Phagocytosis Establishment Of Vesicle Localization Cellular Response To Calcium Ion Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Synaptic Vesicle Endocytosis Regulation Of Defense Response To Bacterium Negative Regulation Of Microglial Cell Activation Negative Regulation Of Membrane Invagination Regulation Of Phagosome Maturation Positive Regulation Of Protein Localization To Phagocytic Vesicle Negative Regulation Of Clathrin-coated Pit Assembly Calcium Ion Regulated Lysosome Exocytosis	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Parkinson's disease ( 21292315 25064009) Serum cancer antigen 15.3 levels ( 31666285) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		6 interacting genes: APPBP2 GPR35 PRKN SGTA SGTB SYNCRIP	32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1
Entrez ID		23208	51177
HPRD ID		12289	12217
Ensembl ID		ENSG00000132718	ENSG00000023902
Uniprot IDs		Q9BT88	Q53GL0 Q5T4P9
PDB IDs			3AA1
Enriched GO Terms of Interacting Partners?
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