KANK1 and BAIAP2

Data Source:
HPRD (in vivo)

		KANK1	BAIAP2
Description		KN motif and ankyrin repeat domains 1	BAR/IMD domain containing adaptor protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Ruffle Membrane	Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Filopodium Extracellular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding	Protein Binding Protein C-terminus Binding Cytoskeletal Anchor Activity Identical Protein Binding Proline-rich Region Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cell Population Proliferation Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wound Healing Glomerular Visceral Epithelial Cell Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Ruffle Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Lamellipodium Morphogenesis	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Bundle Assembly Actin Crosslink Formation Cell-cell Adhesion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Estrogen-dependent gene expression Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases		Cerebral palsy
GWAS		Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Eye morphology ( 29921221) Fasting plasma glucose ( 25187374) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1/FVC ratio ( 26634245) Proinsulin levels (early-phase conversion) ( 23263489) Serum bilirubin levels in metabolic syndrome ( 30621171) Systolic blood pressure ( 30224653) Uterine fibroids ( 30194396)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		9 interacting genes: AKT1 BAIAP2 PPP1CA YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	39 interacting genes: ADGRB1 APP ATN1 BAIAP2L1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 PAK1 PBX2 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SRPK2 TBX5 TP53BP2 WASF1 WASF2 YWHAG
Entrez ID		23189	10458
HPRD ID		09651	05686
Ensembl ID		ENSG00000107104	ENSG00000175866
Uniprot IDs		Q14678	I3L4C2 Q9UQB8
PDB IDs		5YBJ 5YBU	1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?
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