BAIAP2 and LIN7C

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		BAIAP2	LIN7C
Description		BAR/IMD domain containing adaptor protein 2	lin-7 homolog C, crumbs cell polarity complex component
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Filopodium Extracellular Exosome	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding Cytoskeletal Anchor Activity Identical Protein Binding Proline-rich Region Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Bundle Assembly Actin Crosslink Formation Cell-cell Adhesion Positive Regulation Of Actin Cytoskeleton Reorganization	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		39 interacting genes: ADGRB1 APP ATN1 BAIAP2L1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 PAK1 PBX2 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SRPK2 TBX5 TP53BP2 WASF1 WASF2 YWHAG	11 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP3 MPP7 PALS1 PALS2 YES1
Entrez ID		10458	55327
HPRD ID		05686	17279
Ensembl ID		ENSG00000175866	ENSG00000148943
Uniprot IDs		I3L4C2 Q9UQB8	Q9NUP9
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI	3LRA
Enriched GO Terms of Interacting Partners?
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