BAIAP2 and ENAH

Data Source:
HPRD (in vitro, in vivo)

		BAIAP2	ENAH
Description		BAR/IMD domain containing adaptor protein 2	ENAH actin regulator
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Filopodium Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding Cytoskeletal Anchor Activity Identical Protein Binding Proline-rich Region Binding Cadherin Binding Involved In Cell-cell Adhesion	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding WW Domain Binding
	Biological Process	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Bundle Assembly Actin Crosslink Formation Cell-cell Adhesion Positive Regulation Of Actin Cytoskeleton Reorganization	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Delirium ( 29631748) Depression in smokers ( 30219690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 27067015) Obesity-related traits ( 23251661)
Interacting Genes		39 interacting genes: ADGRB1 APP ATN1 BAIAP2L1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 PAK1 PBX2 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SRPK2 TBX5 TP53BP2 WASF1 WASF2 YWHAG	27 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX
Entrez ID		10458	55740
HPRD ID		05686	12360
Ensembl ID		ENSG00000175866	ENSG00000154380
Uniprot IDs		I3L4C2 Q9UQB8	A0A4D6J698 Q8N8S7
PDB IDs		1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI	2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M
Enriched GO Terms of Interacting Partners?
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