M6PR and HSPA12A

Data Source:
BioGRID (two hybrid)

		M6PR	HSPA12A
Description		mannose-6-phosphate receptor, cation dependent	heat shock protein family A (Hsp70) member 12A
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	Molecular_function Protein Binding ATP Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization	Biological_process
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Regulation of HSF1-mediated heat shock response
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4	5 interacting genes: HRAS HSPA12B M6PR NRCAM SORL1
Entrez ID		4074	259217
HPRD ID		01106	19074
Ensembl ID		ENSG00000003056	ENSG00000165868
Uniprot IDs		F5GX30 P20645	A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301
PDB IDs		1JUQ
Enriched GO Terms of Interacting Partners?
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