FCHO1 and GRB7

Data Source:
BioGRID (two hybrid)

		FCHO1	GRB7
Description		FCH and mu domain containing endocytic adaptor 1	growth factor receptor bound protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	Protein Binding AP-2 Adaptor Complex Binding	RNA Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis	Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly ERBB2 Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Leukocyte Migration
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling
Drugs
Diseases
GWAS		Basophil count ( 32888494) Coronary artery disease ( 29212778) Monocyte percentage of white cells ( 32888494)	Asthma ( 31619474 28461288) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 20228799)
Interacting Genes		51 interacting genes: ACVR1 APP BYSL CCDC13 CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15 EPS15L1 EXOSC5 FBXL7 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		23149	2886
HPRD ID		16887	03311
Ensembl ID		ENSG00000130475	ENSG00000141738
Uniprot IDs		A0A0C3SFZ9 B7ZAZ3 O14526	A0A0S2Z4F6 Q14451
PDB IDs			1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q
Enriched GO Terms of Interacting Partners?
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