PHF8 and POLR2A

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PHF8	POLR2A
Description		PHD finger protein 8	RNA polymerase II subunit A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane	Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Chromosome Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Methylated Histone Binding Histone Demethylase Activity (H4-K20 Specific) Histone Demethylase Activity (H3-K36 Specific) Histone Demethylase Activity (H3-K27 Specific)	RNA Polymerase II Activity DNA Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Protein Demethylation Brain Development Histone H3-K9 Demethylation Histone H4-K20 Demethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ribosomal DNA Heterochromatin Assembly Histone H3-K36 Demethylation Histone H3-K27 Demethylation	MRNA Splicing, Via Spliceosome Transcription, RNA-templated Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway Viral Process RNA Metabolic Process Positive Regulation Of RNA Splicing Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA
Pathways		HDMs demethylate histones	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder and schizophrenia ( 21057379)	Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		8 interacting genes: APP H3-4 H3C1 H4C1 POLR2A RARA SUMO2 USP7	108 interacting genes: ABL1 ACTB ACTL6A ASB6 ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 ELL ELOA ERCC5 ERCC6 ERG ESR1 FUS GRB2 GTF2B GTF2E1 GTF2F1 GTF2H1 GTF2H4 H1-2 HNRNPF HNRNPU HTATSF1 IFTAP ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L PPIG PPP1CA PQBP1 PRMT5 PRPF19 PTEN SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUMO2 SUPT5H TAF10 TBP TCEA1 TCERG1 TDRD3 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR WAC XAB2 XRCC5 ZNF74
Entrez ID		23133	5430
HPRD ID		06599	08916
Ensembl ID		ENSG00000172943	ENSG00000181222
Uniprot IDs		O95327 Q9UPP1	P24928
PDB IDs		2WWU 3K3N 3K3O 3KV4 4DO0	2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6IC8 6IC9 6O9L 6Q5Y
Enriched GO Terms of Interacting Partners?
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