PHF8

Description		PHD finger protein 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Methylated Histone Binding Histone Demethylase Activity (H4-K20 Specific) Histone Demethylase Activity (H3-K36 Specific) Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Protein Demethylation Brain Development Histone H3-K9 Demethylation Histone H4-K20 Demethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ribosomal DNA Heterochromatin Assembly Histone H3-K36 Demethylation Histone H3-K27 Demethylation
Pathways		HDMs demethylate histones
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder and schizophrenia ( 21057379)
Interacting Genes		8 interacting genes: APP H3-4 H3C1 H4C1 POLR2A RARA SUMO2 USP7
Entrez ID		23133
HPRD ID		06599
Ensembl ID		ENSG00000172943
Uniprot IDs		O95327 Q9UPP1
PDB IDs		2WWU 3K3N 3K3O 3KV4 4DO0
Enriched GO Terms of Interacting Partners?
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