HECW1 and USP7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HECW1	USP7
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	ubiquitin specific peptidase 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Maintenance Of DNA Methylation Viral Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		Degradation of DVL	Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Chronotype ( 30696823) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		16 interacting genes: CACNA1A DVL1 GFI1B SCNN1A SCNN1B SSR4 TNK2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	103 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ERCC6 EWSR1 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76
Entrez ID		23072	7874
HPRD ID		11385	03950
Ensembl ID		ENSG00000002746	ENSG00000187555
Uniprot IDs		Q76N89	B7Z855 B7ZAX6 Q6U8A4 Q93009
PDB IDs		3L4H	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2
Enriched GO Terms of Interacting Partners?
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