HECW1 and SSR4

Data Source:
HPRD (in vitro, two hybrid)

		HECW1	SSR4
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	signal sequence receptor subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Sec61 Translocon Complex Endomembrane System Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Degradation of DVL	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		16 interacting genes: CACNA1A DVL1 GFI1B SCNN1A SCNN1B SSR4 TNK2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	5 interacting genes: HECW1 NLGN3 POMP PTEN SSR3
Entrez ID		23072	6748
HPRD ID		11385	02101
Ensembl ID		ENSG00000002746	ENSG00000180879
Uniprot IDs		Q76N89	P51571
PDB IDs		3L4H
Enriched GO Terms of Interacting Partners?
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