HECW1 and VAX1

Data Source:
BioGRID (two hybrid)

		HECW1	VAX1
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	ventral anterior homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Neuron Differentiation Skeletal Muscle Cell Differentiation Camera-type Eye Development Roof Of Mouth Development
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 20023658 28054174)
Interacting Genes		16 interacting genes: CACNA1A DVL1 GFI1B SCNN1A SCNN1B SSR4 TNK2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	14 interacting genes: DVL3 EAF1 ESRRG HECW1 HMBOX1 MLLT3 PICK1 POLR3C PSMB1 RCOR3 RPRD1B SDCBP2 SPANXN2 USP20
Entrez ID		23072	11023
HPRD ID		11385	16052
Ensembl ID		ENSG00000002746	ENSG00000148704
Uniprot IDs		Q76N89	Q5SQQ9
PDB IDs		3L4H
Enriched GO Terms of Interacting Partners?
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