KDM2A and POLA2

Data Source:
BioGRID (affinity chromatography technology)

		KDM2A	POLA2
Description		lysine demethylase 2A	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)	Molecular_function DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Protein Demethylation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Histone H3-K36 Demethylation	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		HDMs demethylate histones	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Height ( 28552196 28270201) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 32888494 27863252)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		22992	23649
HPRD ID		05741	10160
Ensembl ID		ENSG00000173120	ENSG00000014138
Uniprot IDs		I3VM53 I3VM54 Q9Y2K7	Q14181
PDB IDs		2YU1 2YU2 4BBQ 6BYH 6C16	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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