LMTK2 and CDK5R1

Data Source:
HPRD (two hybrid, in vitro)

		LMTK2	CDK5R1
Description		lemur tyrosine kinase 2	cyclin dependent kinase 5 regulatory subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Integral Component Of Membrane Growth Cone Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Myosin VI Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protease Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Receptor Recycling Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Endocytic Recycling Negative Regulation Of Phosphoprotein Phosphatase Activity Transferrin Transport Positive Regulation Of Kinase Activity Early Endosome To Late Endosome Transport Protein Autophosphorylation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Microtubule Polymerization Neuron Projection Development Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Serine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Regulation Of Synaptic Vesicle Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways			CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5
Drugs			Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097)
Interacting Genes		24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2	31 interacting genes: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		22853	8851
HPRD ID		13994	04586
Ensembl ID		ENSG00000164715	ENSG00000176749
Uniprot IDs		Q8IWU2	Q15078 Q8N619
PDB IDs			1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG
Enriched GO Terms of Interacting Partners?
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