MRAS and RALGDS

Data Source:
HPRD (two hybrid, in vitro)

		MRAS	RALGDS
Description		muscle RAS oncogene homolog	ral guanine nucleotide dissociation stimulator
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		RAF activation Signaling by MRAS-complex mutants	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Systolic blood pressure ( 27841878)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		22808	5900
HPRD ID		06662	03371
Ensembl ID		ENSG00000158186	ENSG00000160271
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	Q12967 Q8N4Y1
PDB IDs			1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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