ALDH2 and HSPB2

Data Source:
BioGRID (two hybrid)

		ALDH2	HSPB2
Description		aldehyde dehydrogenase 2 family member	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Mitochondrial Matrix Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Electron Transfer Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Catabolic Process Ethanol Oxidation Electron Transport Chain	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways		Metabolism of serotonin Ethanol oxidation
Drugs		NADH Guanidine Disulfiram Daidzin Crotonaldehyde
Diseases		Acute alcohol sensitivity
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 24277619 29460428) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 25249183) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 23364009 21372407) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Fish intake frequency ( 31959922) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) Hypertension ( 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tofu consumption ( 31959922) Triglycerides ( 22171074 26582766) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Yoghurt consumption ( 31959922)
Interacting Genes		14 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 RPL13A SIRT3 SLC35F6 UNC119	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		217	3316
HPRD ID		00003	03712
Ensembl ID		ENSG00000111275	ENSG00000170276
Uniprot IDs		A0A384NPN7 P05091	A8KAH6 Q16082
PDB IDs		1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13	6F2R
Enriched GO Terms of Interacting Partners?
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