EYA2 and DTX2

Data Source:
BioGRID (two hybrid)

		EYA2	DTX2
Description		EYA transcriptional coactivator and phosphatase 2	deltex E3 ubiquitin ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Notch Signaling Pathway Protein Ubiquitination
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		35 interacting genes: AATK BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FAM214B GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C	131 interacting genes: ABHD11 ABHD16A ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C11orf1 C19orf54 C1orf94 C20orf85 C22orf39 CCDC57 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PPP1R32 PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUSC1 SEC22A SEC23A SEC23B SEPSECS SLC22A18AS SOHLH1 SPAG8 SPG21 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		2139	113878
HPRD ID		09041	16841
Ensembl ID		ENSG00000064655	ENSG00000091073
Uniprot IDs		E7ETN2 O00167	Q86UW9
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?
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