EYA2 and LGALS4

Data Source:
BioGRID (two hybrid)

		EYA2	LGALS4
Description		EYA transcriptional coactivator and phosphatase 2	galectin 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding	Protein Binding Galactoside Binding Carbohydrate Binding
	Biological Process	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Adhesion
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		35 interacting genes: AATK BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FAM214B GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C	16 interacting genes: ARPC3 BANP CEP55 EYA2 GOLGA6L9 HOMEZ HOXA1 HSF2BP KIAA1549 KRTAP11-1 MLH1 NCKIPSD RFX6 RRAS2 TENM4 TOX2
Entrez ID		2139	3960
HPRD ID		09041	03949
Ensembl ID		ENSG00000064655	ENSG00000171747
Uniprot IDs		E7ETN2 O00167	P56470 Q6FHZ4
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX
Enriched GO Terms of Interacting Partners?
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