EPHB6 and POU6F2

Data Source:
BioGRID (two hybrid)

		EPHB6	POU6F2
Description		EPH receptor B6	POU class 6 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex	Chromatin Nucleus
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Signaling Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Ganglion Mother Cell Fate Determination Central Nervous System Development Visual Perception
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Cancer ( 29299148)	Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 31959993 30054594) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)
Interacting Genes		27 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39	143 interacting genes: ACTN3 ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C1orf109 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574
Entrez ID		2051	11281
HPRD ID		04133	10162
Ensembl ID		ENSG00000106123	ENSG00000106536
Uniprot IDs		F8WCM8 J3KQU5 O15197	P78424
PDB IDs
Enriched GO Terms of Interacting Partners?
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