EIF4A2 and EIF4G2

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (in vitro)

		EIF4A2	EIF4G2
Description		eukaryotic translation initiation factor 4A2	eukaryotic translation initiation factor 4 gamma 2
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon
	Molecular Function	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism
Drugs
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2
Entrez ID		1974	1982
HPRD ID		03062	09084
Ensembl ID		ENSG00000156976	ENSG00000110321
Uniprot IDs		Q14240	P78344 Q2TU89
PDB IDs		3BOR	3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
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