EIF4A2 and CLNS1A

Data Source:
HPRD (two hybrid)

		EIF4A2	CLNS1A
Description		eukaryotic translation initiation factor 4A2	chloride nucleotide-sensitive channel 1A
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol Cytoskeleton Plasma Membrane Methylosome PICln-Sm Protein Complex
	Molecular Function	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity	RNA Binding Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Spliceosomal SnRNP Assembly Chloride Transport Cell Volume Homeostasis
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	snRNP Assembly
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30224653) Platelet distribution width ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	17 interacting genes: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 FRMD7 ITGA2B LSM10 LSM3 LSM6 PRMT5 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPG WDR77
Entrez ID		1974	1207
HPRD ID		03062	03694
Ensembl ID		ENSG00000156976	ENSG00000074201
Uniprot IDs		Q14240	E9PJF4 E9PMI6 J3KN38 P54105
PDB IDs		3BOR	6V0O
Enriched GO Terms of Interacting Partners?
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