PGAM5 and SETDB1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PGAM5	SETDB1
Description		PGAM family member 5, mitochondrial serine/threonine protein phosphatase	SET domain bifurcated histone lysine methyltransferase 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Phosphatase Activity GTPase Activator Activity Protein Binding Phosphatase Activity Protein-containing Complex Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Promoter-specific Chromatin Binding
	Biological Process	Protein Dephosphorylation Macroautophagy Positive Regulation Of GTPase Activity Necroptotic Process Negative Regulation Of Cold-induced Thermogenesis	Ras Protein Signal Transduction Negative Regulation Of Gene Expression Response To Vitamin Response To Ethanol Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Body mass index ( 26426971) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		30 interacting genes: HSPA1B MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR141 MIR145 MIR15A MIR16-1 MIR18B MIR200B MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR34A MIR451A MIR93 MIRLET7A1 MIRLET7A2 MIRLET7B MIRLET7E MIRLET7F1 SETDB1 UBE4B YWHAG ZBTB16	109 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4-16 HDAC1 HDAC2 HMOX2 HSF2BP HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24
Entrez ID		192111	9869
HPRD ID		14681	06828
Ensembl ID		ENSG00000247077	ENSG00000143379
Uniprot IDs		Q96HS1	Q15047
PDB IDs		3MXO 3O0T 5MUF 6CNI 6CNL	3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?