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SETDB1 and SIN3A
Data Source:
HPRD
(in vivo)
SETDB1
SIN3A
Description
SET domain bifurcated histone lysine methyltransferase 1
SIN3 transcription regulator family member A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Intracellular Membrane-bounded Organelle
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity (H3-K9 Specific)
Promoter-specific Chromatin Binding
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Biological Process
Ras Protein Signal Transduction
Negative Regulation Of Gene Expression
Response To Vitamin
Response To Ethanol
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Histone H3-K9 Methylation
Heterochromatin Organization
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
PKMTs methylate histone lysines
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Chronic kidney disease (
20383146
)
Coffee consumption (
31046077
)
Cutaneous squamous cell carcinoma (
32041948
)
Melanoma (
21983785
)
Neurological blood protein biomarker levels (
31320639
)
Nevus count or cutaneous melanoma (
30429480
)
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Interacting Genes
109 interacting genes:
AIFM1
AKT1
ANXA7
APC
APLP1
ASAH1
ATF7IP
ATF7IP2
BAG6
BARD1
BHLHE40
BID
BRIX1
BTBD2
C11orf1
CBX8
CCDC106
CDK4
CDKN1A
CLSTN1
CREBBP
CRELD1
DAP
DLEU1
DNMT3A
ECSIT
ERG
ERH
FAM118B
FLYWCH1
GIPC2
GPS2
GRB7
GSTO1
H3-4
H3C1
H3C15
H4-16
HDAC1
HDAC2
HMOX2
HSF2BP
HSPB3
JARID2
KDM1A
LRIF1
LUC7L2
MAD2L1BP
MAP4K5
MBD1
MDM2
MOB4
MRPL44
MZT2B
NIPSNAP3A
OLFML3
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PGAM5
PHF10
PIAS4
PLEKHA4
POLA2
PPA1
PPP1R8
PRKRA
PSMD11
PSME1
PTPRS
QTRT1
RIF1
RNF10
S100A10
SAT1
SERPINB9
SIN3A
SIN3B
SKIL
SLC38A3
SMN1
SNIP1
SUFU
SULT1E1
SUMO2
TARDBP
TCERG1
THAP8
TK1
TOB1
TOLLIP
TPI1
TRBV2
TRDMT1
TRIB3
TRIM16
TRIM28
TRIP6
TSC22D1
TTR
TXNDC9
UBE2I
ULK2
USP11
VIM
ZFP64
ZNF24
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
Entrez ID
9869
25942
HPRD ID
06828
09690
Ensembl ID
ENSG00000143379
ENSG00000169375
Uniprot IDs
Q15047
Q96ST3
PDB IDs
3DLM
4X3S
5KCH
5KCO
5KE2
5KE3
5KH6
5QT1
5QT2
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
1PO4
Enriched GO Terms of Interacting Partners
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