PHC2 and AFG3L2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHC2	AFG3L2
Description		polyhomeotic homolog 2	AFG3 like matrix AAA peptidase subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Metallopeptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Negative Regulation Of Transcription, DNA-templated	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Mitochondrial Calcium Ion Homeostasis Righting Reflex Protein-containing Complex Assembly
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Processing of SMDT1
Drugs			ATP
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167
Entrez ID		1912	10939
HPRD ID		10340	05205
Ensembl ID		ENSG00000134686	ENSG00000141385
Uniprot IDs		A0A0A0MSI2 Q8IXK0	Q8TA92 Q9Y4W6
PDB IDs			2LNA 6NYY
Enriched GO Terms of Interacting Partners?
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