AFG3L2 and RAC2

Data Source:
BioGRID (two hybrid)

		AFG3L2	RAC2
Description		AFG3 like matrix AAA peptidase subunit 2	Rac family small GTPase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex	Nuclear Envelope Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Metallopeptidase Activity Zinc Ion Binding Unfolded Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Mitochondrial Calcium Ion Homeostasis Righting Reflex Protein-containing Complex Assembly	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Cell Redox Homeostasis Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Processing of SMDT1	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		ATP	Dextromethorphan
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS			Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167	22 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		10939	5880
HPRD ID		05205	03628
Ensembl ID		ENSG00000141385	ENSG00000128340
Uniprot IDs		Q8TA92 Q9Y4W6	A0A024R1P2 P15153 V9H0H7
PDB IDs		2LNA 6NYY	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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