PHC2 and ZGPAT

Data Source:
BioGRID (two hybrid)

		PHC2	ZGPAT
Description		polyhomeotic homolog 2	zinc finger CCCH-type and G-patch domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 30388399) Crohn's disease ( 28067908) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462) High density lipoprotein cholesterol levels ( 31928498) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1) ( 28166213) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 31562322 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633) Waist circumference ( 31928498)
Interacting Genes		79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	77 interacting genes: AIMP2 AMOTL2 BEND5 BLZF1 C1D CARD9 CAVIN4 CCDC13 CCDC196 CCDC33 CCDC57 CCHCR1 CCNDBP1 CDCA7L CDR2 CEP57L1 CEP70 CNKSR1 CTNNA1 DHX15 DVL2 DYDC1 EP400 FAM9B GATAD2B GOLGA2 GOLGA6L9 HOOK2 HSF2BP IHO1 IKZF3 KIAA1328 KIFC3 KRT15 KRT31 KRT40 LCA5L LDOC1 LNX1 LZTS1 LZTS2 MID2 MIPOL1 NEBL PHC2 PPP1R13B PRPF3 S100A10 SCNM1 SERTAD3 SNRPA1 SPAG5 SSX2IP STAC3 TADA2B TFIP11 THAP1 THAP6 TLE5 TP53BP2 TRIM14 TRIM27 TRIM54 UBXN11 UPF2 ZBTB8A ZC2HC1B ZNF177 ZNF24 ZNF329 ZNF426 ZNF559-ZNF177 ZNF587 ZNF688 ZNF71 ZSCAN22 ZXDB
Entrez ID		1912	84619
HPRD ID		10340	15736
Ensembl ID		ENSG00000134686	ENSG00000197114
Uniprot IDs		A0A0A0MSI2 Q8IXK0	A0A0S2Z5X3 Q8N5A5
PDB IDs			4II1
Enriched GO Terms of Interacting Partners?
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