AFG3L2 and RNF167

Data Source:
BioGRID (two hybrid)

		AFG3L2	RNF167
Description		AFG3 like matrix AAA peptidase subunit 2	ring finger protein 167
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex	Cytoplasm Endomembrane System Integral Component Of Membrane
	Molecular Function	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Metallopeptidase Activity Zinc Ion Binding Unfolded Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Mitochondrial Calcium Ion Homeostasis Righting Reflex Protein-containing Complex Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle
Pathways		Processing of SMDT1
Drugs		ATP
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Blood metabolite levels ( 24816252) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167	17 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 MYH7 SLC22A18 SUMO1 TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2K UBE2N UBE2W
Entrez ID		10939	26001
HPRD ID		05205	15261
Ensembl ID		ENSG00000141385	ENSG00000108523
Uniprot IDs		Q8TA92 Q9Y4W6	I3L0L6 Q9H6Y7
PDB IDs		2LNA 6NYY
Enriched GO Terms of Interacting Partners?
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