DSP and JUP

Data Source:
HPRD (two hybrid, in vivo)

		DSP	JUP
Description		desmoplakin	junction plakoglobin
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc Artenimol Zinc acetate	Zinc Zinc acetate
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 31710517 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)	Heel bone mineral density ( 30598549 28869591)
Interacting Genes		31 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 CSTA DES DSC1 ENO3 EVPL IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM	52 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		1832	3728
HPRD ID		00513	01414
Ensembl ID		ENSG00000096696	ENSG00000173801
Uniprot IDs		B4DKX6 P15924 Q4LE79	A0A0S2Z487 P14923
PDB IDs		1LM5 1LM7 3R6N 5DZZ	3IFQ
Enriched GO Terms of Interacting Partners?
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