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JUP and DSG2
Data Source:
HPRD
(in vivo)
JUP
DSG2
Description
junction plakoglobin
desmoglein 2
Image
GO Annotations
Cellular Component
Cornified Envelope
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Zonula Adherens
Fascia Adherens
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Actin Cytoskeleton
Apicolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Z Disc
Hemidesmosome
Desmosome
Protein-DNA Complex
Specific Granule Lumen
Extracellular Exosome
Gamma-catenin-TCF7L2 Complex
Ficolin-1-rich Granule Lumen
Cornified Envelope
Plasma Membrane
Cell-cell Junction
Cell Surface
Intercalated Disc
Integral Component Of Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Desmosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Nuclear Hormone Receptor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Alpha-catenin Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Cytoskeletal Protein-membrane Anchor Activity
Calcium Ion Binding
Cell Adhesion Molecule Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Desmosome Assembly
Cell Migration
Keratinization
Adherens Junction Organization
Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Import Into Nucleus
Neutrophil Degranulation
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Positive Regulation Of DNA-binding Transcription Factor Activity
Cornification
Endothelial Cell-cell Adhesion
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Positive Regulation Of Canonical Wnt Signaling Pathway
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Desmosome Organization
Purkinje Myocyte Development
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Keratinization
Response To Progesterone
Maternal Process Involved In Female Pregnancy
Cornification
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways
Adherens junctions interactions
VEGFR2 mediated vascular permeability
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
Apoptotic cleavage of cell adhesion proteins
Keratinization
Formation of the cornified envelope
Drugs
Zinc
Zinc acetate
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS
Heel bone mineral density (
30598549
28869591
)
Blood protein levels (
30072576
29875488
)
Interacting Genes
52 interacting genes:
APC
ARHGDIA
AXIN1
BIRC2
BRCA1
BTRC
CCDC130
CDH1
CDH10
CDH15
CDH2
CDH5
CTNNA1
CTNNA3
CTNNBIP1
CTNND1
DDX6
DSC1
DSC2
DSC3
DSG1
DSG2
DSG3
DSP
EGFR
ERBB2
ERBB3
FER
FHL2
FYN
MUC1
NFATC4
NFKBIE
NTAQ1
PECAM1
PKD1
PKP2
PKP3
PRR35
PSEN1
PTEN
PTPN14
PTPRF
PTPRJ
PTPRK
RIBC2
RSPH14
SRC
TBP
TCF4
TCF7L2
ZFYVE9
5 interacting genes:
DSC1
DSC2
JUP
PKP2
PKP3
Entrez ID
3728
1829
HPRD ID
01414
00516
Ensembl ID
ENSG00000173801
ENSG00000046604
Uniprot IDs
A0A0S2Z487
P14923
Q14126
PDB IDs
3IFQ
2YQG
5ERD
5J5J
6QNT
6QNU
6SIT
7AGF
7AGG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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