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JUP and PECAM1
Data Source:
HPRD
(in vivo, in vitro)
JUP
PECAM1
Description
junction plakoglobin
platelet and endothelial cell adhesion molecule 1
Image
GO Annotations
Cellular Component
Cornified Envelope
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Zonula Adherens
Fascia Adherens
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Actin Cytoskeleton
Apicolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Z Disc
Hemidesmosome
Desmosome
Protein-DNA Complex
Specific Granule Lumen
Extracellular Exosome
Gamma-catenin-TCF7L2 Complex
Ficolin-1-rich Granule Lumen
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Secretory Granule Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Nuclear Hormone Receptor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Alpha-catenin Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Cytoskeletal Protein-membrane Anchor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Desmosome Assembly
Cell Migration
Keratinization
Adherens Junction Organization
Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Import Into Nucleus
Neutrophil Degranulation
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Positive Regulation Of DNA-binding Transcription Factor Activity
Cornification
Endothelial Cell-cell Adhesion
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Positive Regulation Of Canonical Wnt Signaling Pathway
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Phagocytosis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Recognition
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Maintenance Of Blood-brain Barrier
Monocyte Extravasation
Neutrophil Degranulation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Diapedesis
Establishment Of Endothelial Barrier
Bicellular Tight Junction Assembly
Glomerular Endothelium Development
Neutrophil Extravasation
Cell-cell Adhesion
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways
Adherens junctions interactions
VEGFR2 mediated vascular permeability
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
Platelet degranulation
Cell surface interactions at the vascular wall
PECAM1 interactions
Integrin cell surface interactions
Platelet sensitization by LDL
Neutrophil degranulation
Drugs
Zinc
Zinc acetate
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
GWAS
Heel bone mineral density (
30598549
28869591
)
Coronary artery disease (
32469254
29212778
33020668
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
)
Interacting Genes
52 interacting genes:
APC
ARHGDIA
AXIN1
BIRC2
BRCA1
BTRC
CCDC130
CDH1
CDH10
CDH15
CDH2
CDH5
CTNNA1
CTNNA3
CTNNBIP1
CTNND1
DDX6
DSC1
DSC2
DSC3
DSG1
DSG2
DSG3
DSP
EGFR
ERBB2
ERBB3
FER
FHL2
FYN
MUC1
NFATC4
NFKBIE
NTAQ1
PECAM1
PKD1
PKP2
PKP3
PRR35
PSEN1
PTEN
PTPN14
PTPRF
PTPRJ
PTPRK
RIBC2
RSPH14
SRC
TBP
TCF4
TCF7L2
ZFYVE9
22 interacting genes:
CD38
CSK
CTNNB1
DSP
EFNB2
FYN
HCK
INPP5D
ITGA5
ITGB3
JUP
LCK
LYN
PIK3R1
PLCG1
PRKCE
PRPF40A
PTPN11
PTPN6
SRC
XRCC6
YES1
Entrez ID
3728
5175
HPRD ID
01414
01425
Ensembl ID
ENSG00000173801
ENSG00000261371
Uniprot IDs
A0A0S2Z487
P14923
P16284
PDB IDs
3IFQ
2KY5
5C14
5GNI
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Intersection)
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