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DSP and CASP2
Data Source:
HPRD
(in vitro)
DSP
CASP2
Description
desmoplakin
caspase 2
Image
GO Annotations
Cellular Component
Cornified Envelope
Nucleus
Cytoplasm
Intermediate Filament
Plasma Membrane
Fascia Adherens
Intercalated Disc
Membrane
Basolateral Plasma Membrane
Desmosome
Extracellular Exosome
Ficolin-1-rich Granule Membrane
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Molecular Function
RNA Binding
Protein Kinase C Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Scaffold Protein Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Desmosome Organization
Ventricular Compact Myocardium Morphogenesis
Epidermis Development
Peptide Cross-linking
Keratinocyte Differentiation
Keratinization
Adherens Junction Organization
Wound Healing
Neutrophil Degranulation
Skin Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Cornification
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Epithelial Cell-cell Adhesion
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Protein Localization To Cell-cell Junction
Luteolysis
Neural Retina Development
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Brain Development
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Protein Processing
Ectopic Germ Cell Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Cellular Response To Mechanical Stimulus
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
NOD1/2 Signaling Pathway
NADE modulates death signalling
TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Zinc
Artenimol
Zinc acetate
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
Striate palmoplantar keratoderma
Skin fragility-woolly hair syndrome
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Chronic obstructive pulmonary disease (
28166215
30804561
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Idiopathic pulmonary fibrosis (
31710517
29066090
)
Interstitial lung disease (
23583980
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Numerical cognitive ability (
31620175
)
PR interval (
32439900
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Resting heart rate (
27798624
)
Interacting Genes
31 interacting genes:
ARID3A
CASP10
CASP2
CASP4
CASP6
CASP7
CASP9
CDC42
CDH5
COL17A1
CSTA
DES
DSC1
ENO3
EVPL
IVL
JUP
KRT1
KRT5
KRT6A
MTDH
PECAM1
PKP1
PKP2
PKP3
PKP4
PRKACA
PRKCE
PTEN
UCHL5
VIM
31 interacting genes:
ADCYAP1
BAG4
BID
CASP10
CASP14
CASP3
CASP7
CASP8
CCND3
CFLAR
CRADD
CSNK2A1
DCTN1
DSP
EEF1A1
GOLGA3
GRB2
KPNA2
MDM2
MZB1
NLRP1
NOD1
NOL3
PIDD1
PRKAB2
RAI1
RB1
RPL30
RXRA
SUMO1
UBE2I
Entrez ID
1832
835
HPRD ID
00513
02800
Ensembl ID
ENSG00000096696
ENSG00000106144
Uniprot IDs
B4DKX6
P15924
Q4LE79
A0A087WYM1
A0A0S2Z3H1
D3DXD9
P42575
PDB IDs
1LM5
1LM7
3R6N
5DZZ
1PYO
2P2C
3R5J
3R6G
3R6L
3R7B
3R7N
3R7S
3RJM
6GKF
6GKG
6S9K
6SAD
Enriched GO Terms of Interacting Partners
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