DSG3 and PKP3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		DSG3	PKP3
Description		desmoglein 3	plakophilin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Integral Component Of Membrane Desmosome Extracellular Exosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding	RNA Binding Protein Binding Enzyme Binding Translation Regulator Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Cornification Cell-cell Adhesion	Desmosome Assembly Regulation Of Translation Cell-cell Junction Assembly Positive Regulation Of Gene Expression Keratinization Cornification Protein Localization To Plasma Membrane Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways		Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629) Survival in colon cancer ( 25866641)	Anorectal malformation ( 31136621) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		4 interacting genes: CASP3 FURIN JUP PKP3	10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18
Entrez ID		1830	11187
HPRD ID		01355	05711
Ensembl ID		ENSG00000134757	ENSG00000184363
Uniprot IDs		P32926	Q9Y446
PDB IDs		5EQX
Enriched GO Terms of Interacting Partners?
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