PKP3 and DSG3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PKP3	DSG3
Description		plakophilin 3	desmoglein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Cell Junction Desmosome Messenger Ribonucleoprotein Complex	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Integral Component Of Membrane Desmosome Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Translation Regulator Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion	Calcium Ion Binding
	Biological Process	Desmosome Assembly Regulation Of Translation Cell-cell Junction Assembly Positive Regulation Of Gene Expression Keratinization Cornification Protein Localization To Plasma Membrane Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Cornification Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Parkinson's disease (age of onset) ( 19772629) Survival in colon cancer ( 25866641)
Interacting Genes		10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18	4 interacting genes: CASP3 FURIN JUP PKP3
Entrez ID		11187	1830
HPRD ID		05711	01355
Ensembl ID		ENSG00000184363	ENSG00000134757
Uniprot IDs		Q9Y446	P32926
PDB IDs			5EQX
Enriched GO Terms of Interacting Partners?
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