DSG2 and PKP3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		DSG2	PKP3
Description		desmoglein 2	plakophilin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	RNA Binding Protein Binding Enzyme Binding Translation Regulator Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Response To Progesterone Maternal Process Involved In Female Pregnancy Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Desmosome Assembly Regulation Of Translation Cell-cell Junction Assembly Positive Regulation Of Gene Expression Keratinization Cornification Protein Localization To Plasma Membrane Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways		Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Blood protein levels ( 30072576 29875488)	Anorectal malformation ( 31136621) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3	10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18
Entrez ID		1829	11187
HPRD ID		00516	05711
Ensembl ID		ENSG00000046604	ENSG00000184363
Uniprot IDs		Q14126	Q9Y446
PDB IDs		2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7AGF 7AGG
Enriched GO Terms of Interacting Partners?
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