DIO2 and UBE2G1

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)

		DIO2	UBE2G1
Description		iodothyronine deiodinase 2	ubiquitin conjugating enzyme E2 G1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Cytosol Extracellular Exosome
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Regulation of thyroid hormone activity	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	19 interacting genes: AMFR APP CBL CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 UBA1 UBE2E1 UBE3A
Entrez ID		1734	7326
HPRD ID		09027	03340
Ensembl ID		ENSG00000211448	ENSG00000132388
Uniprot IDs		A8K845 Q92813	P62253
PDB IDs			2AWF 6D68
Enriched GO Terms of Interacting Partners?
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