DIO2 and WSB1

Data Source:
BioGRID (enzymatic study)

		DIO2	WSB1
Description		iodothyronine deiodinase 2	WD repeat and SOCS box containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	Protein Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Protein Polyubiquitination Biological_process Intracellular Signal Transduction Post-translational Protein Modification
Pathways		Regulation of thyroid hormone activity	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)	Birth weight ( 31043758) Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	7 interacting genes: CSF3R DIO2 GSK3B HIPK2 LRRK2 UBE2D2 UBE2D3
Entrez ID		1734	26118
HPRD ID		09027	15680
Ensembl ID		ENSG00000211448	ENSG00000109046
Uniprot IDs		A8K845 Q92813	A0A024QZ36 A0A024QZ51 Q8NC76 Q9Y6I7
PDB IDs
Enriched GO Terms of Interacting Partners?
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