TNF and CSF1

Data Source:
HPRD (in vivo)

		TNF	CSF1
Description		tumor necrosis factor	colony stimulating factor 1
Image
GO Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Humoral Immune Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Virus Response To Salt Stress Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Fractalkine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Viral Genome Replication Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Positive Regulation Of JNK Cascade Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Astrocyte Activation Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization Defense Response To Gram-positive Bacterium Cognition Leukocyte Tethering Or Rolling Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Death-inducing Signaling Complex Assembly Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Endothelial Cell Apoptotic Process Protein Localization To Plasma Membrane Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Interleukin-33 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration
Pathways		Transcriptional regulation of white adipocyte differentiation TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation
Drugs		Etanercept Adalimumab Infliximab Chloroquine Epinephrine Pseudoephedrine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone Afelimomab YSIL6 SD118 PN0621 OMS-103HP Talmapimod VX-702 Atiprimod CRx-139 CYT007-TNFQb Andrographolide Ethyl pyruvate AME-527 PR-104 Plinabulin Dexanabinol Onercept Golimumab Certolizumab pegol Pomalidomide Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Bryostatin 1 Binimetinib Dilmapimod Glycyrrhizic acid
Diseases		Graft-versus-host disease Asthma Allograft rejection Systemic lupus erythematosus
GWAS		AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cervical cancer ( 28806749) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Neonatal lupus ( 20662065) Psychosis (atypical) ( 24132900) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 29403010) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Height ( 31562340) Lactate dehydrogenase levels ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein level ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		53 interacting genes: ADAM17 ADAM9 AQP3 BCL2L13 BGN BTNL9 C10orf67 CCDC107 CCDC70 CLDN7 CLEC10A CREB3L1 CSF1 CYB5R3 DCN FAM209A FFAR2 FNDC9 FYN IFNG KASH5 LMNA LRRC25 LRRTM2 LYN MMP17 MRM3 NFKBIA PAGE1 PANX1 PDIK1L PIP4P2 PLEKHO1 POU2F1 PRTN3 RC3H1 RIPK1 RNF19B SEC61A1 SGCB SLC14A2 SLC30A4 SSMEM1 STOM STX1A TMPRSS2 TNFRSF1A TNFRSF1B TRAF2 VSIR YWHAQ ZCCHC12 ZFP36	13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF
Entrez ID		7124	1435
HPRD ID		01855	00388
Ensembl ID		ENSG00000232810	ENSG00000184371
Uniprot IDs		P01375 Q5STB3	A0A024R0A1 P09603
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6OOY 6OOZ 6OP0 6RMJ	1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF
Enriched GO Terms of Interacting Partners?
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