COMMD6 and COMMD1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro)

		COMMD6	COMMD1
Description		COMM domain containing 6	copper metabolism domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome
	Molecular Function	Protein Binding NF-kappaB Binding	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of NF-kappaB Transcription Factor Activity	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways		Neddylation	Neddylation
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)	Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		3 interacting genes: COMMD1 COMMD9 HSPA6	31 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT XIAP
Entrez ID		170622	150684
HPRD ID		13084	06253
Ensembl ID		ENSG00000188243	ENSG00000173163
Uniprot IDs		Q7Z4G1	Q8N668
PDB IDs			2H2M
Enriched GO Terms of Interacting Partners?
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