DHX15 and SPOP

Data Source:
BioGRID (two hybrid)

		DHX15	SPOP
Description		DEAH-box helicase 15	speckle type BTB/POZ protein
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Toxic Substance Response To Alkaloid	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		mRNA Splicing - Major Pathway	Hedgehog 'on' state
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)	Prostate cancer ( 23535732)
Interacting Genes		21 interacting genes: AGGF1 APBB1 CAMSAP3 DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN RBM17 SPOP TRA2A UBC WBP4 YWHAB YWHAG ZGPAT	66 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		1665	8405
HPRD ID		04553	16004
Ensembl ID		ENSG00000109606	ENSG00000121067
Uniprot IDs		O43143	O43791
PDB IDs		5XDR 6ID1 6SH6 6SH7	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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