DDX11 and KAT7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DDX11	KAT7
Description		DEAD/H-box helicase 11	lysine acetyltransferase 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Spindle Pole Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Midbody Mitotic Cohesin Complex Ctf18 RFC-like Complex Extracellular Exosome	Histone Acetyltransferase Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Histone H3-K14 Acetyltransferase Complex Site Of DNA Damage
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity RNA-dependent ATPase Activity Triplex DNA Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding	DNA Replication Origin Binding Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Multicellular Organism Development Viral Process Replication Fork Processing Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding DNA Duplex Unwinding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding IRE1-mediated Unfolded Protein Response G-quadruplex DNA Unwinding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair	Natural Killer Cell Differentiation DNA Replication DNA Repair Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Regulation Of DNA-dependent DNA Replication Initiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of DNA-templated Transcription, Elongation Histone H3 Acetylation Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin Positive Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Nucleotide-excision Repair
Pathways		XBP1(S) activates chaperone genes	HATs acetylate histones
Drugs
Diseases		Warsaw breakage syndrome
GWAS			Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean reticulocyte volume ( 32888494)
Interacting Genes		2 interacting genes: KAT7 PFN2	44 interacting genes: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 MCRS1 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165
Entrez ID		1663	11143
HPRD ID		03095	07135
Ensembl ID		ENSG00000013573	ENSG00000136504
Uniprot IDs		Q2NKM7 Q96FC9	O95251
PDB IDs			5GK9 6MAJ 6MAK
Enriched GO Terms of Interacting Partners?
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