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SMARCB1 and PDPK1
Data Source:
BioGRID
(two hybrid)
SMARCB1
PDPK1
Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
3-phosphoinositide dependent protein kinase 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
SWI/SNF Complex
Protein-containing Complex
Brahma Complex
Intracellular Membrane-bounded Organelle
NpBAF Complex
NBAF Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Perikaryon
Molecular Function
RNA Polymerase I Core Promoter Sequence-specific DNA Binding
P53 Binding
DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Tat Protein Binding
Nucleosomal DNA Binding
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Insulin Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Protein Kinase Binding
Phospholipase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
RNA Polymerase I Preinitiation Complex Assembly
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Nervous System Development
DNA Integration
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
ATP-dependent Chromatin Remodeling
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K9 Dimethylation
Negative Regulation Of Histone H3-K9 Trimethylation
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Glucose Mediated Signaling Pathway
Positive Regulation Of Histone H3-K9 Acetylation
Regulation Of Histone H4-K16 Acetylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Type B Pancreatic Cell Development
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Activation Of Protein Kinase B Activity
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mast Cell Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Focal Adhesion Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Fractional shortening (
29403010
)
IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) (
28878392
)
IgG digalactosylation phenotypes (multivariate analysis) (
28878392
)
IgG disialylation phenotypes (multivariate analysis) (
28878392
)
IgG fucosylation phenotypes (multivariate analysis) (
28878392
)
IgG galactosylation phenotypes (multivariate analysis) (
28878392
)
IgG glycosylation (
23382691
)
IgG monogalactosylation phenotypes (multivariate analysis) (
28878392
)
IgG N-glycosylation phenotypes (multivariate analysis) (
28878392
32128391
)
IgG sialylation phenotypes (multivariate analysis) (
28878392
)
N-glycan levels (
31163085
)
Interacting Genes
112 interacting genes:
ABI2
AKT1
APP
ARL11
ATP5F1A
BCL2L11
BHLHE40
BLZF1
CALR
CAMK2D
CCDC120
CCDC33
CD69
CDC23
CDX2
CEBPB
CHFR
CXCL11
CYB5D2
DNAJA3
DPH6
FAM90A1
FAM9B
FUS
GADD45G
GATA1
GFAP
GOLGA2
HGS
HNRNPM
HOMEZ
HOOK2
HSF2BP
HSFY1
IHO1
IKZF3
IL16
KCTD9
KLC3
KLF1
KMT2B
KMT2C
KPNA6
KRT15
KRT19
KRT6A
KRT6B
KRT6C
LDOC1
LENG8
LNX2
LY96
LZTS2
MAP1LC3B
MAP3K20
MAPK8IP2
MBIP
MCPH1
MECP2
MESD
MIF4GD
MRPL53
MXI1
MYC
NCK2
NONO
NR0B2
NR3C1
OSGIN1
OTX2
PDPK1
PICK1
PPP1CC
PPP1R15A
PRKAB2
PRMT5
PSMB1
RAN
RB1
RELB
RINT1
RPN1
RPS6KA5
RUSC1
RXRA
SAXO1
SIN3B
SMARCA4
SMARCC2
SMARCD1
SRC
TACC2
TAF1D
TASOR2
TEKT5
TFIP11
TLE5
TNFAIP1
TNRC6A
TP53
TRIM14
TRIM27
TRIM35
TSC22D4
UBQLN4
VIM
XPO1
YEATS4
ZC3H11A
ZDHHC17
ZNF398
ZNF688
60 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
DDIT4
GIT1
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
LUC7L2
MAPK8
MTOR
PAK1
PEA15
PHAX
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SLC9A3R2
SMARCB1
SOCS3
SRC
SRPK1
STRAP
TCAP
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
6598
5170
HPRD ID
03364
05556
Ensembl ID
ENSG00000099956
ENSG00000140992
Uniprot IDs
G5E975
Q12824
Q9H836
O15530
PDB IDs
5AJ1
5GJK
5L7A
5L7B
6AX5
6KAG
6KZ7
6LTH
6LTJ
6UCH
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
Enriched GO Terms of Interacting Partners
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