OXER1 and MED25

Data Source:
BioGRID (two hybrid)

		OXER1	MED25
Description		oxoeicosanoid receptor 1	mediator complex subunit 25
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		Eicosanoid ligand-binding receptors G alpha (i) signalling events	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Attention deficit hyperactivity disorder ( 18821565) Breastfeeding duration ( 25475840) Hyperactive-impulsive symptoms ( 18821565)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		46 interacting genes: ANAPC11 ARRB2 ASB13 ATG9A CCNK CRYBA2 EFCAB3 ESRP1 FOXH1 HNF1B HNRNPH1 INTS11 JMJD7 KRTAP12-3 KRTAP19-5 KRTAP4-2 KRTAP5-6 KRTAP6-3 LASP1 MED25 NCS1 NEK8 NOC4L OTX1 PLSCR4 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 RAMAC RBFOX2 RECK RNF208 RNF38 RNF44 TFG TLE5 TP53BP1 VGLL3 ZBTB32 ZC3H10 ZIC1	37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		165140	81857
HPRD ID		17812	14380
Ensembl ID		ENSG00000162881	ENSG00000104973
Uniprot IDs		Q8TDS5	Q71SY5
PDB IDs			2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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