CLEC14A and EMD

Data Source:
BioGRID (two hybrid)

		CLEC14A	EMD
Description		C-type lectin domain containing 14A	emerin
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Microtubule Membrane Integral Component Of Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum
	Molecular Function	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Lymphangiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway	Muscle Contraction Mitotic Nuclear Envelope Reassembly Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Resveratrol
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3	98 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SOWAHB SRC SSMEM1 STX1A STX4 SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAPB VAV1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774
Entrez ID		161198	2010
HPRD ID		10711	02309
Ensembl ID		ENSG00000176435	ENSG00000102119
Uniprot IDs		Q86T13	P50402
PDB IDs			1JEI 2ODC 2ODG 6GHD 6RPR
Enriched GO Terms of Interacting Partners?
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