PPM1L and TRIM59

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)

		PPM1L	TRIM59
Description		protein phosphatase, Mg2+/Mn2+ dependent 1L	tripartite motif containing 59
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Protein Dephosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		3 interacting genes: EPHA2 MAP3K7 PDGFRB	26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		151742	286827
HPRD ID		17889	15568
Ensembl ID		ENSG00000163590	ENSG00000213186
Uniprot IDs		Q5SGD2	Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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