CTSH and CSTA

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		CTSH	CSTA
Description		cathepsin H	cystatin A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Thyroid Hormone Binding	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Proteolysis Involved In Cellular Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cornification Cell-cell Adhesion
Pathways		MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation	Formation of the cornified envelope
Drugs		N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases		Type I diabetes mellitus
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576 29875488) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244 24076602) Narcolepsy ( 23459209) Type 1 diabetes ( 25751624 19430480 30572963 18978792)	Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)
Interacting Genes		5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1	12 interacting genes: CTSB CTSH CTSL DSP EVPL IVL KRT1 LORICRIN PI3 PTN UCHL5 ZDHHC17
Entrez ID		1512	1475
HPRD ID		00288	01697
Ensembl ID		ENSG00000103811	ENSG00000121552
Uniprot IDs		P09668	P01040
PDB IDs		1BZN 6CZK 6CZS	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE
Enriched GO Terms of Interacting Partners?
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