CSTA and CTSH

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		CSTA	CTSH
Description		cystatin A	cathepsin H
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Thyroid Hormone Binding
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cornification Cell-cell Adhesion	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Proteolysis Involved In Cellular Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus
Pathways		Formation of the cornified envelope	MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation
Drugs			N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases			Type I diabetes mellitus
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576 29875488) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244 24076602) Narcolepsy ( 23459209) Type 1 diabetes ( 25751624 19430480 30572963 18978792)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL DSP EVPL IVL KRT1 LORICRIN PI3 PTN UCHL5 ZDHHC17	5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		1475	1512
HPRD ID		01697	00288
Ensembl ID		ENSG00000121552	ENSG00000103811
Uniprot IDs		P01040	P09668
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE	1BZN 6CZK 6CZS
Enriched GO Terms of Interacting Partners?
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