CSTA and DSP

Data Source:
BioGRID (pull down)

		CSTA	DSP
Description		cystatin A	desmoplakin
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cornification Cell-cell Adhesion	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Artenimol Zinc acetate
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)	Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 31710517 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL DSP EVPL IVL KRT1 LORICRIN PI3 PTN UCHL5 ZDHHC17	31 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 CSTA DES DSC1 ENO3 EVPL IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM
Entrez ID		1475	1832
HPRD ID		01697	00513
Ensembl ID		ENSG00000121552	ENSG00000096696
Uniprot IDs		P01040	B4DKX6 P15924 Q4LE79
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE	1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?
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