CTSH and SFTPB

Data Source:
HPRD (in vitro)

		CTSH	SFTPB
Description		cathepsin H	surfactant protein B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Thyroid Hormone Binding	Protein Binding
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Proteolysis Involved In Cellular Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus	Sphingolipid Metabolic Process Respiratory Gaseous Exchange By Respiratory System Animal Organ Morphogenesis Cellular Protein Metabolic Process
Pathways		MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation	Surfactant metabolism Defective pro-SFTPB causes SMDP1 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases		Type I diabetes mellitus	Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576 29875488) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244 24076602) Narcolepsy ( 23459209) Type 1 diabetes ( 25751624 19430480 30572963 18978792)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1	2 interacting genes: CTSH MEOX2
Entrez ID		1512	6439
HPRD ID		00288	01523
Ensembl ID		ENSG00000103811	ENSG00000168878
Uniprot IDs		P09668	D6W5L6 P07988
PDB IDs		1BZN 6CZK 6CZS	1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU 2M0H 2M1T
Enriched GO Terms of Interacting Partners?
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