LAYN and KMT2A

Data Source:
BioGRID (enzymatic study)

		LAYN	KMT2A
Description		layilin	lysine methyltransferase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Focal Adhesion Cell Surface Integral Component Of Membrane	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex
	Molecular Function	Hyaluronic Acid Binding Carbohydrate Binding	Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Lysine-acetylated Histone Binding
	Biological Process		Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs		Hyaluronic acid
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Fish- and plant-related diet ( 32066663) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: DEFB121 GIMAP5 IGFBP5 MFSD11 PLPP6 RHOU	31 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H3-3A H3-4 H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5
Entrez ID		143903	4297
HPRD ID		17299	01162
Ensembl ID		ENSG00000204381	ENSG00000118058
Uniprot IDs		B4DDS5 Q6UX15	Q03164
PDB IDs			2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R
Enriched GO Terms of Interacting Partners?
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