CRMP1 and CACNA1A

Data Source:
BioGRID (two hybrid)

		CRMP1	CACNA1A
Description		collapsin response mediator protein 1	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Nucleus Centrosome Spindle Cytosol Growth Cone Midbody Perikaryon	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Filamin Binding Identical Protein Binding	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance Negative Regulation Of Neuron Projection Development Negative Regulation Of Actin Filament Binding	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		CRMPs in Sema3A signaling	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		80 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		1400	773
HPRD ID		03913	03004
Ensembl ID		ENSG00000072832	ENSG00000141837
Uniprot IDs		B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		4B3Z	3BXK
Enriched GO Terms of Interacting Partners?
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